Changes and Significance of Coagulation Function,Serum IL-6,IL-10 and SIL-2R Levels Before and After Massive Blood Transfusion in Patients with Severe Trauma

Zhu Rui; Liu Huan

doi:10.3969/j.issn.1004-5775.2025.08.019

Abstract：Objective:To explore the changes and significance of coagulation function,serum interleukin-6(IL-6),IL-10 and soluble interleukin-2 receptor(sIL-2R)in patients with severe trauma before and after massive blood transfusion.Methods:50 patients with severe trauma in the hospital from October 2022 to September 2023 were selected as the research subjects.The changes of coagulation function indexes,serum IL-6,IL-10 and sIL-2R levels before and after massive blood transfusion were compared,and the correlation between the above indexes and massive blood transfusion was analyzed.Results:There were some changes in coagulation function indexes of patients before and after blood transfusion,among which PT,APTT and TT were longer after blood transfusion,and compared at different time after blood transfusion,the above indexes were longer,and the levels of FIB and PLT were lower after blood transfusion,while compared at different time after blood transfusion,the above indexes were lower,with statistically significant difference(F=159.983,184.764,150.693,136.547,1 209.002;P＜0.001).The changes of potassium ion and sodium ion in patients before and after blood transfusion were significant.After 1 and 3 days of blood transfusion,the potassium ion level was higher than that before blood transfusion.3 days after blood transfusion,the potassium ion level was longer than that after 1 day of blood transfusion.The sodium ion level was lower than that before blood transfusion,and the difference was statistically significant(F=11.252,200.733;P＜0.001).The serum levels of IL-6,IL-10 and sIL-2R changed significantly before and after blood transfusion.1 day and 3 days after blood transfusion,the potassium ion level was higher than that before blood transfusion,and the above indexes were higher after 1 day of blood transfusion than after 3 days of blood transfusion,with statistically significant difference(F=969.690,297.761,224.263;P＜0.001).Pearson linear analysis showed that massive blood transfusion was positively correlated with PT,APTT TT,IL-6,IL-10 and sIL-2R(r=0.423,0.523,0.417,0.423,0.323,0.412;P＜0.05),and negatively correlated with FIB and PLT(r=-0.378,-0.223;P＜0.05).Conclusion:Large amount of blood transfusion can help severely injured patients recover their blood volume as soon as possible,but their coagulation function indicators and serum levels of IL-6,IL-10 and sIL-2R may change to some extent.Therefore,medical staff should dynamically monitor the above indicators during large amount of blood transfusion to prevent coagulation dysfunction and immune suppression,which may threaten life safety.