Effect of Ultrasound-guided Thoracic Paravertebral Nerve Block Combined with General Anesthesia on Cognitive Impairment in Elderly Patients Undergoing Thoracoscopic Lobectomy
Ren Yan
Li Fushen
Yang Yun
Abstract：Objective:To investigate the effect of ultrasound-guided thoracic paravertebral block(CTPVB)combined with general anesthesia in elderly patients with thoracoscopic lobectomy.Methods:70 elderly patients undergoing thoracoscopic lobectomy in the hospital from March 2021 to March 2023 were divided into two groups according to the random number table method,with 35 cases in each group.The control group was given simple general anesthesia,and the observation group was given CTPVB combined with general anesthesia.The incidence of postoperative cognitive dysfunction(POCD),cognitive function and adiponectin(ADP)levels were compared between the two groups.Results:The incidence of POCD in the observation group was 5.71％(2/35)24 h after operation,which was lower than 25.71％(9/35)in the control group(x2=5.285,P＜0.05).The MMSE scores of the observation group 12 h,24 h and 48 h after operation were higher than those of the control group(t=65.244,52.874,59.531;P＜0.001).15 min after biopsy,the levels of ADP in the two groups decreased,but the levels of ADP in the observation group were higher than those in the control group(t=59.841,76.305;P＜0.001).Conclusion:CTPVB combined with general anesthesia is more effective in elderly patients undergoing thoracoscopic lobectomy,with less impact on cognitive function,lower incidence of POCD,and smaller fluctuation of ADP level.
Keywords：Thoracoscopic lobectomyUltrasound-guided thoracic paravertebral nerve blockGeneral anesthesiaCognitive function
Publication Date：2025-04-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 951-953 )