Analysis of the Diagnostic Value of ApoB/ApoA-1 Ratio,Hs-CRP and CK-MB in the Detection of Coronary Artery Lesions in Elderly Patients with Coronary Heart Disease

Wang Yan; Wang Zhijian; Ma Haiyan

doi:10.3969/j.issn.1004-5775.2025.08.008

Abstract：Objective:To evaluate the diagnostic value of apolipoprotein B/apolipoprotein A1(ApoB/ApoA-1)ratio,hypersensitive C-reactive protein(hs-CRP)and creatine kinase isoenzyme(CK-MB)in detecting the degree of coronary artery in elderly patients with coronary artery disease.Methods:100 elderly patients with coronary artery disease in the hospital from January 2021 to January 2023 were selected as the research object,and their serum ApoB/ApoA-1 ratio,hs-CRP and CK-MB levels were measured.Patients were divided into different groups according to the severity of coronary artery lesions,and the differences of serum ApoB/ApoA-1 ratio,hs-CRP and CK-MB were compared.Spearman analysis of the correlation between ApoB/ApoA-1 ratio,hs-CRP,CK-MB levels and the degree of coronary artery disease in elderly patients with coronary artery disease was conducted.The subject worker characteristic curve(ROC)was drawn to evaluate the diagnostic value of ApoB/ApoA-1 ratio,hs-CRP and CK-MB in detecting the degree of coronary artery disease in elderly patients with coronary artery disease.Results:According to the results of coronary angiography,the patients with coronary artery disease in this group were divided into three groups:31 patients in the mild group,37 patients in the moderate group and 32 patients in the severe group.From the mild group,the moderate group to the severe group,the level of ApoB/ApoA-1 ratio hs-CRP and CK-MB continued to increase,and the difference between the two groups was statistically significant(F=28.392,8.842,13.868;P＜0.001).Spearman correlation analysis showed that the ratio of ApoB/ApoA-1,the levels of hs-CRP and CK-MB were positively correlated with the degree of coronary artery disease(r=0.618,0.384,0.471;P＜0.001).The AUC of the ratio of ApoB/ApoA-1,hs-CRP and CK-MB in detecting the degree of coronary artery disease in elderly patients were 0.815,0.714 and 0.745 respectively.Conclusion:ApoB/ApoA-1 ratio,hs-CRP,CK-MB have positive correlation with the degree of coronary artery disease in elderly patients,which can be used for clinical diagnosis of coronary artery disease.