Effect of Ultrasound-guided Percutaneous Nephrolithotomy in Treating Renal Calculi and its Influence on Inflammatory Trauma Response

Liu Dongdong; Li Shu; Li Bei

doi:10.3969/j.issn.1004-5775.2025.08.007

Abstract：Objective:To explore the effect of ultrasound-guided percutaneous nephrolithotomy(PCNL)in the treatment of renal calculi and its influence on inflammatory trauma response.Methods:96 patients with renal calculi in the hospital from June 2018 to June 2023 were selected as the observation subjects.All patients received PCNL treatment and were numbered according to the order of admission.They were divided into study group(48 cases)and control group(48 cases)by adopting the random number table method.The control group received standard channel PCNL,while the study group was given ultrasound-guided microchannel PCNL.The perioperative indicators,one-time stone clearance rate,secondary surgery rate,renal function[serum creatinine(Scr),blood urea nitrogen(BUN)],inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),monocyte chemoattractant protein-1(MCP-1)]and complications were compared between groups.Results:The intraoperative blood loss of the study group was significantly less than that of the control group,the hospitalization time was significantly shorter than that of the control group,and the operation time was significantly longer than that of the control group,with statistically significant difference(t=11.245,7.540,11.754;P＜0.05).There was no significant difference in one-time stone clearance between the two groups(x2=2.700,P＞0.05).After operation,the levels of IL-6,TNF-α,MCP-1,IL-6,TNF-α and MCP-1 in 2 groups were significantly higher than those before operation.There was no significant difference in the incidence of complications between two groups(x2=0.381,P＞0.05).Conclusion:Ultrasound-guided microchannel PCNL in the treatment of renal calculi can reduce the intraoperative blood loss,shorten the hospital stay and inhibit the inflammatory trauma response,but standard channel PCNL has shorter surgical time and smaller impact on renal function.