Predictive Efficacy of Peripheral Blood Inflammatory Cells on the Risk of Postoperative Recurrence of Gallbladder Cancer

Meng Yu

doi:10.3969/j.issn.1004-5775.2025.08.004

Abstract：Objective:To analyze the predictive efficacy of peripheral blood inflammatory cells on the risk of postoperative recurrence of gallbladder cancer.Methods:113 patients with gallbladder cancer who underwent surgery in the hospital from January 2021 to August 2023 were selected as the research subjects.All patients have received radical surgery for gallbladder cancer treatment.According to whether the postoperative condition relapses,the enrolled patients were divided into recurrent group(33 cases)and non recurrent group(80 cases).General and clinical data of the two groups were collected and compared.The risk factors that can lead to postoperative recurrence of gallbladder cancer patients through statistical univariate analysis and logistic multiple regression analysis.NLR,PLR,MLR,SIRI and other peripheral blood inflammatory cell indicators between the recurrent and non recurrent groups were compared.The predictive efficacy of these indicators on the risk of postoperative disease recurrence in patients by plotting ROC were evaluated,and AUC was observed.Results:The results of statistical single factor analysis showed that in the recurrence group,the TNM stage of tumor was＞Ⅱ B stage,histological grade＞Ⅱ stage,carcinoembryonic antigen(CEA)＞5 n/mL,carbohydrate antigen 19-9(CA199)＞27,the proportion of U/mL,total protein(TP＜60g/L,albumin(ALB)＜35g/L,transferrin(TRF)＜2.5g/L,NLR＞4.0,PLR＞130,ML＞0.25,SIRI＞1.19 were higher than those in non-recurrence group.The difference was statistically significant(x2=8.075,8.496,12.960,7.748,4.889,7.956,6.185,24.529,35.027,21.778,56.609;P＜0.05).Logistic regression analysis showed that NLR＞4.0,PLR＞130,MLR＞0.25,SIRI＞1.19 were risk factors for postoperative recurrence of gallbladder cancer(OR=3.297,3.631,3.707,3.628;P＜0.05).NLR,PLR,MLR and SIRI in the relapse group were higher than those in the non-relapse group,and the differences were statistically significant(t=4.413,3.510,11.005,11.520;P＜0.05).After ROC curve verification,NLR,PLR,MLR and SIRI showed high predictive efficacy(AUC＞0.85)for postoperative recurrence risk of gallbladder cancer.Conclusion:Inflammatory response in the body is a risk factor for postoperative recurrence in patients with gallbladder cancer.Peripheral blood inflammatory cell markers have a high predictive power for postoperative recurrence in patients,with NLR=4.0,PLR=130,MLR=0.25 and SIRI=1.19 being the best cutoff values for predicting the risk of recurrence.