Study on the Relationship Between FGF23 and Anemia in Patients with Chronic Kidney Disease on Stage 5 Dialysis

Li Li; Zhang Xi; Li Jun

doi:10.3969/j.issn.1004-5775.2025.08.001

Abstract：Objective:To investigate the relationship between Fibroblast growth factor 23(FGF23),klotho protein and anemia in Chronic kidney disease stage 5(CKD5)dialysis patients.Methods:40 CKD5 stage anemia patients who underwent dialysis in the hospital from May 2022 to February 2023 were selected as the observation group,and 40 CKD5 stage non anemia patients who underwent dialysis during the same period were selected as the control group.Serum albumin(ALB),serum Ferritin(FER),parathyroid hormone(PTH),total calcium ion(Ca2+),serum phosphorus(P),Klotho,FGF23 protein levels were compared between the two groups.The correlation between FGF23,Klotho and ALB,FER,PTH,Ca2+and P were observed.Results:The levels of ALB and Ca2+in observation group were higher than those in control group,while the levels of PTH and P in observation group were lower than those in control group,with statistical significance(t=0.502,P＜0.05;U=-3.998,-4.171,-2.789;P＜0.05).The FGF23 level in observation group was higher than that in control group,and the Klotho protein level in observation group was lower than that in control group,with statistically significant difference(t=1 0.453,18.286;P＜0.05).FGF23 was positively correlated with P(r=0.568),and negatively correlated with ALB and PTH(r=-0.096,-0.288).Klotho protein was positively correlated with ALB and PTH(r=0.146,0.182),and negatively correlated with P(r=0.415),and the differences were statistically significant(P＜0.05).The area under ROC curve(AUC)of Klotho protein,FCF23 and Klotho protein-FCF23 were 0.869,0.857 and 0.881,respectively.The specificity was 82.7％,81.6％and 81.5％.And the sensitivity was 87.8％,91.9％and 92.2％,respectively.Conclusion:There is correlation between Klotho,FCF23 and ALB,PTH,Ca2+,P in CKD5 dialysis anemia patients.Klotho protein and FGF23 protein have high predictive value for CKD5 dialysis anemia and can be used as monitoring indicators.