Controlled Clinical Experimental Study of Cypofol or Propofol in Elderly Patients During Induction of General Anesthesia

Mo Zhiwei; Huang Wusheng; Peng Jiabiao

doi:10.3969/j.issn.1004-5775.2025.07.013

Abstract：Objective:To investigate the safety and clinical effect of targeted infusion of cypofol or propofol in the induction period of general anesthesia in elderly patients,and to provide evidence for the selection of appropriate drugs for the induction period of general anesthesia in elderly patients.Methods:A total of 144 elderly patients undergoing general anesthesia surgery in Traditional Chinese Medical Hospital of Gaozhou from August 2022 to August 2023 were selected as the study objects,and randomly divided into cyclopofol induction group and propofol induction group,with 72 cases in each group.During the induction period of general anesthesia,targeted infusion of cyclopofol and propofol were respectively administered,and the induction time,total amount of studied drugs and plasma target concentration,vital signs and adverse reactions at each time point of the two groups were compared.Results:The total drug amount and average plasma target concentration in cyclopofol induction group were lower than those in propofol induction group,and the differences were statistically significant(t=14.115,16.135;P＜0.05).At T1,T2,and T3,HR,MAP,SBP,DBP,BIS,CI,SV,and CO indexes in both groups showed a downward trend,while SVV indexes showed an upward trend,with statistically significant difference(t=5.084,5.147,5.007;5.903,12.184,13.648,4.979,4.503,3.819,14.655,11.273,9.199,0.382,0.187,0.294,5.062,10.406,14.149,2.972,5.704,7.995,2.784,2.903,3.277,3.555,6.601,15.493;P＜0.05).The incidence of adverse reactions in cyclopofol induced group was lower than that in propofol induced group,and the difference was statistically significant(x2=49.000,P＜0.001).Conclusion:Both cipofol and propofol can achieve clinical anesthetic effects in elderly patients during the induction period of general anesthesia,but cipofol infusion can significantly reduce the dose of drugs,reduce the impact on patients'vital signs,and reduce the incidence of adverse reactions,with high safety and worthy of promotion.