Role of Small Intestinal Bacterial Overgrowth in Patients with Liver Cirrhosis in Gastrointestinal Symptoms

Wang Huimin

doi:10.3969/j.issn.1004-5775.2025.07.008

Abstract：Objective:To investigate the role of intestinal bacterial overgrowth in patients with cirrhosis in gastrointestinal tract.Methods:63 patients with cirrhosis and 40 healthy physical examinees were included as the control group.According to the child-pugh score of A,B and C,the difference of digestive tract symptom score was compared with that of healthy control group.Digestive tract symptom scores of SIBO positive and negative were compared in patients with cirrhosis.The score of digestive tract symptoms of patients with SIBO(+)and(-)before and after treatment,and those with negative or still positive were compared.Results:The scores of digestive tract symptoms in grade A,grade B and grade C patients with Child-Pugh cirrhosis were higher than those in healthy control group,and the differences were statistically significant(t=7.47,8.27,10.16;P＜0.05).The digestive tract score of the cirrhosis positive group was higher than that of the negative group,and there was statistical difference between the two groups(t=2.23,P＜0.05).20 of 42 patients with SIBO positive cirrhosis turned negative after rifaximin treatment,and the score of gastrointestinal symptoms after treatment was lower than that before treatment,and the difference was statistically significant(t=3.46,P＜0.05).The score of gastrointestinal symptoms in patients with SIBO turning negative after treatment was lower than that in patients with SIBO remaining positive,and the difference was statistically significant(t=-2.53,P＜0.05).Conclusion:Patients with liver cirrhosis are prone to SIBO.It is one of the causes of gastrointestinal symptoms in patients with liver cirrhosis.After intervention with rifaximin,SIBO was partially inhibited.It can relieve gastrointestinal symptoms in patients with cirrhosis.