Prediction of Serum miR-92b Levels for Postoperative Recurrence in Patients with Thoracic Esophageal Cancer Undergoing Thoracoscopic Surgery
Wang Qixin
Zhu Zhengshuai
Yang Zilin
Abstract：Objective:To explore the predictive value of serum microRNA-92b(miR-92b)for postoperative recurrence in patients with thoracic esophageal cancer undergoing thoracoscopy.Methods:A prospective study was conducted on 150 patients with thoracic esophageal cancer who underwent thoracoscopic esophagectomy in the hospital from June 2019 to June 2022.All patients underwent miR-92b real-time fluorescence quantitative PCR detection before surgery.A follow-up period of 12 months was conducted after surgery,and the cancer recurrence rate of patients during the follow-up period was counted.Patients were divided into recurrence group and non recurrence group based on the outcome.A baseline data questionnaire was designed to include possible factors,focusing on the relationship between serum miR-92b level and postoperative recurrence in patients with thoracic esophageal cancer.Receiver operating characteristic(ROC)curve was drawn to analyze the value of serum miR-92b level in predicting postoperative recurrence in patients with thoracic esophageal cancer.Results:Among 150 patients with thoracic esophageal cancer,31 recurred after thoracoscopic operation,and 119 did not.The expression level of miR-92b in the recurrent group was lower than that in the non-recurrent group,and the difference was statistically significant(t=4.446,P＜0.001).Logistic regression analysis showed that the degree of cancer tissue infiltration and TNM stage Ⅲ were risk factors for patients with thoracoscopic postoperative recurrence(OR=4.609,4.775;P＜0.05),and preoperative serum miR-92b overexpression was a protective factor for patients with thoracoscopic postoperative recurrence(OR=0.001,P＜0.05).Results of ROC curve show that preoperative serum miR-92b predicted the AUC of thoracoscopic postoperative recurrence in patients with thoracic esophageal cancer was 0.742,indicating moderate predictive value.Conclusion:Low expression of miR-92b before thoracoscopic surgery is associated with postoperative recurrence in patients with thoracic esophageal cancer.Early detection of miR-92b expression before surgery can be used to predict the risk of postoperative recurrence.
Keywords：Thoracic esophageal cancerThoracoscopic esophagectomy for esophageal cancerMicroRNA-92bRecurrencePrediction
Publication Date：2025-03-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 647-650 )