Comparative Study on the Effects of Butylphthalide and Urinary Kallidinogenase on Cerebrovascular Reserve Function and Vascular Endothelial Function in Patients with Large Artery Atherosclerosis Stroke
Liu Dongfang
Sun Ming
He Feifei
Abstract：Objective:To comparatively analyze the effects of butylphthalide and urinary kallidinogenase on cerebrovascular reserve function and vascular endothelial function in patients with large artery atherosclerosis(LAA)stroke.Methods:Using a random number table,206 patients with LAA stroke admitted to the hospital from January 2020 to December 2023 were divided into butylphthalide group(103 patients treated with butylphthalide)and urinary kallidinogenase group(103 patients treated with urinary kallidinogenase).The two groups were compared in terms of clinical effects,vascular reserve function,vascular endothelial function,collateral circulation and its related factors,and adverse reactions.Results:The total clinical effective rate in the urinary kallidinogenase group was significantly higher than that in the butylphthalide group(x2=4.696,P＜0.05).After 2 weeks of treatment,CVR and BHI in the urinary kallidinogenase group were significantly higher than those in the butylphthalide group(t=14.235,4.142,8.119;P＜0.05).After 2 weeks of treatment,the levels of ET-1,TXB2 and Lp-PLA2 in the urinary kallidinogenase group were significantly lower than those in the butylphthalide group(t=18.478,7.770,9.700;P＜0.05).After 2 weeks of treatment,the levels of CBF,bFGF and BDNF in the urinary kallidinogenase group were significantly higher than those in the butylphthalide group(t=11.481,9.078,7.992;P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(x2=0.354,P＞0.05).Conclusion:Compared with butylphthalide,urinary kallidinogenase is more effective in treating LAA stroke.It can achieve better effects in improving cerebrovascular reserve function,vascular endothelial function,collateral circulation and related factors.Clinical safety of the two treatment methods is comparable.
Keywords：Large artery atherosclerosis strokeButylphthalideUrinary kallidinogenaseVascular reserve functionVascular endothelial function
Publication Date：2025-03-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 583-585 )