Protective Effect and Mechanism of Huangjing Polysaccharide on Gastric Mucosa in Rats with Gastric Ulcer
Jia Chunhui
Li Jing
Niu Meilan
Abstract：Objective:To investigate the effects of Polygonatum polysaccharides on gastrin(GAS),somatostatin(SS),inflammatory factors,and oxidative levels in Gastric Ulcer(GU)rats.Methods:50 rats with gastric ulcers were randomly divided into a model group,a low,medium,and high dose group of Polygonatum polysaccharide,and an omeprazole group,with 10 rats in each group.Except for the blank group and the model group,the other groups were given corresponding drugs by gavage for 8 weeks.Gastrohormone(GAS),growth hormone inhibitor(SS),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),superoxide dismutase(SOD)activity,malondialdehyde(MAD)and glutathione peroxidase(GSH-Px)contents were detected by ELISA.Results:Compared with the blank group,SS decreased(F=271.066,P＜0.05),gastrin(GAS),IL-6 and TNF-α increased(F=278.373,164.100,115.230;P＜0.05),SOD and GSH-Px were significantly decreased(F=279.723,87.303;P＜0.01)in model group.Conclusion:Huangjing polysaccharide has anti-inflammatory and antioxidant effects,as well as protective effects on gastric mucosa in ulcerated rats.Its mechanism is related to upregulating SS,SOD and GSH-Px,and downregulating GAS,MDA,IL-6 and TNF-α.
Keywords：Polygonatum polysaccharideGastric ulcerGastrointestinal hormone regulationInflammatory oxidation
Publication Date：2025-03-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 556-558 )