Application of Remazolam in Anesthesia for Elderly Thoracic and Lumbar Vertebral Fracture Surgery

Zhang Wenjie

doi:10.3969/j.issn.1004-5775.2025.05.010

Abstract：Objective:To observe the application effect of Remazolam in anesthesia for elderly patients with thoracolumbar vertebral fractures surgery.Methods:112 patients with thoracolumbar vertebral compression fractures admitted to the hospital from February 2022 to September 2023 were randomly selected.And they were divided into two groups:the conventional group(56 cases)and the remimazolam group(56 cases).The conventional group received conventional general anesthesia assisted surgery,while the remimazolam group received remimazolam combined with general anesthesia assisted surgery.The perioperative respiratory and circulatory function,blood circulation function,postoperative sedation and analgesia,and anesthesia safety between two groups of patients were compared.Results:Under different anesthesia regimens,the mean intraoperative respiratory rate in the remazolam group was slightly lower than that in the conventional group,and the mean respiratory resistance index(RI)was slightly higher than that in the conventional group(t=1.369,1.520;P＞0.05).The mean operating heart rate(HR)and mean arterial pressure(MAP)of the remazolam group were slightly lower than those of the control group(t=0.406,0.760;P＞0.05).The Ramsay sedation score(RSS)in the Remazolam group 1 h,3 h,5 h and 7 h after surgery was higher than that in the control group,and the Visual Analog Pain Scale(VAS)score was lower than that in the control group,with statistically significant difference(t=5.742,7.690,10.620,31.929,10.135,7.045,7,375,9.914;P＜0.05).The incidence of anesthesia related side effects in the Rimazolam group was slightly higher than that in the conventional group,and the difference was not statistically significant(t=0.121,P＞0.05).Conclusion:Remazolam assisted general anesthesia can enhance postoperative sedation and analgesia without affecting perioperative respiratory and circulatory functions in patients undergoing thoracolumbar fracture surgery.The combined use of this drug dose not significantly increase the risk of anesthesia side effects,and its safety is relatively high.