Analysis of the Drug Resistance Spectrum in 97 Strains of Methicillin-resistant Staphylococcus Aureus
Pu Qiaohong
Chen Zhili
Yang Tong
Abstract：Objective:To analyze the drug resistance spectrum and multidrug resistance of 97 clinical isolates of methicillin-resistant Staphylococcus aureus(MRSA)in 2020,so as to provide reference for rational drug use in clinical practice.Methods:The sensitivity of MRSA to different antibiotics was tested using the Kirby-Bauer disk diffusion method,while the minimum inhibitory concentration(MIC)of different antibiotics against the 97 MRSA strains was determined using the broth microdilution method.Analysis of their drug resistance spectrum and multidrug resistance was done.Results:Among the 97 clinical isolates of MRSA,78 strains,accounting for 80.41％,exhibited characteristics of multidrug-resistant bacteria,resulting in a multidrug resistance index(MARI)of 0.506 9.The resistance rates for penicillin and erythromycin were both above 90.00％,with values of 94.85％and 90.72％respectively.Additionally,the resistance rates for oxacillin,cefotaxime,clindamycin,ciprofloxacin,tetracycline,and ceftazidime were also high,exceeding 50％in all cases.However,MRSA demonstrated low resistance rates(RR≤5.00％)to sulfamethoxazole-trimethoprim,linezolid,and vancomycin.In conclusion,the prevalence of multidrug resistance among clinically isolated MRSA is alarmingly high.Conclusion:It is crucial to address not only the resistance to β-lactam antibiotics but also the resistance to macrolides,lincomycin,tetracyclines,and fluoroquinolones.Therefore,regular monitoring is essential to ensure the appropriate use of antibiotics in clinical practice.
Keywords：Staphylococcus aureusMRSAMultiple drug resistanceDrug resistance spectrum
Publication Date：2025-02-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 462-465 )