Clinical Observation of Hysteromyoma Stripping Combined with Letrozole in Treatment of Hysteromyoma

Zhang Yanyan; Li Dong; Gao Yingqiao

doi:10.3969/j.issn.1004-5775.2025.03.010

Abstract：Objective:To compare the clinical observation of laparoscopic uterine fibroid combined with postoperative trazole in the treatment of uterine fibroid and its influence on serum E2 and ER levels.Methods:76 female patients with uterine fibroid who were treated in the hospital from January 2020 to December 2022 were collected as research objects,and they were divided into control group(n=38)and study group(n=38)by random number table method.Both the control group and the study group received laparoscopic uterine fibroid removal,while the study group took letrozole orally the second day after the operation,once a day,2.5 mg each time,for three months.By comparing the serum E2 and ER levels of the two groups before and 1 month after operation,the recurrence of uterine fibroid 1 month,6 months and 12 months after the operation and the incidence of adverse reactions within 12 months after the operation were compared.Results:1 month after surgery,E2and ER levels in the study group were significantly lower than those in the control group(t=10.831,11.168;P＜0.05).After surgery,the total recurrence rate of uterine fibroids in the study group was significantly lower than that in the control group(x2=5.208,P＜0.05).Within 12 months after operation,the total incidence of adverse reactions,including vomiting,nausea,lower abdominal pain,fatigue and anal distention in the study group was significantly lower than that in the control group,with statistically significant difference(x2=4.547,P＜0.05).Conclusion:The combined treatment scheme of laparoscopic uterine fibroid and subsequent trazole for Uterine fibroid has provided patients with a more comprehensive and individualized treatment scheme,and improves the treatment effect and quality of life.