Value of High Frequency Ultrasound Combined with Serum CA125,CA199 and CYFRA21-1 in Differential Diagnosis of Breast Mass

Gao Sujuan; Zou Yingying; Meng Fanfan

doi:10.3969/j.issn.1004-5775.2025.02.022

Abstract：Objective:To investigate the value of high frequency ultrasound combined with serum CA125,CA199 and CYFRA21-1 in the differential diagnosis of breast mass.Methods:A total of 120 patients with breast mass admitted to the hospital from June 2021 to April 2023 were selected and divided into malignant group(86 cases)and benign group(34 cases)with surgical or pathological biopsy as the gold standard.The results of high-frequency ultrasound diagnosis of breast mass were statistically analyzed.The serum levels of CA125,CA199,CYFRA21-1 and their combined diagnostic results were compared between the two groups,and their diagnostic value was analyzed separately and in combination.Results:Compared with the benign group,the malignant group had irregular shape,unclear boundary,calcification,uneven echo and aspect ratio＞1,with statistically significant difference(χ2=91.962,79.099,53.861,72.881,90.133;P＜0.05).Serum levels of CA125,CA199 and CYFRA21-1 in malignant group were significantly higher than those in benign group(t=27.986,18.877,15.019;P＜0.05).The sensitivity and accuracy of HF ultrasound combined with serum CA125,CA199 and CYFRA21-1 were higher than that of single diagnosis,and the rate of missed diagnosis was lower than that of single diagnosis(χ2=17.425,21.217,17.425;P＜0.05).Conclusion:The combined diagnosis of high frequency ultrasound,serum CA125,CA199,CYFRA21-1 can significantly improve the diagnostic sensitivity,reduce the rate of missed diagnosis,and provide reliable basis for clinical diagnosis of breast mass.