Effect of Early Enteral Nutrition Support on Elderly Patients After Hepatectomy

Yan Honghui; Zhang Erjuan; Xu Xinhong

doi:10.3969/j.issn.1004-5775.2025.02.015

Abstract：Objective:To explore the effect of early enteral nutrition(EEN)support on nutritional status,intestinal mucosal barrier function and liver function in elderly patients after liver resection.Methods:A total of 129 elderly patients after liver resection in the hospital from March 2020 to March 2022 were selected as research objects,and they were divided into trational nutrition group and enteral nutrition group.64 patients in the traditional nutrition group received conventional nutrition support,and 65 patients in the enteral nutrition group received early enteral nutrition support.The nutritional status,intestinal mucosal barrier function,liver function and 1-year survival rate of the two groups were compared.Results:After intervention,the amounts of hemoglobin(Hb),albumin(Alb),transferrin(TRF),prealbumin(PA)and red blood cell(RBC)in enteral nutrition group were higher than those in traditional nutrition group,with statistically significant difference(t=6.091,3.864,5.337,6.807,13.193;P＜0.001).After intervention,the levels of D-lactic acid(D-lac),diamine oxidase(DAO)and endotoxin(ET)in enteral nutrition group were lower than those in traditional nutrition group,with statistically significant difference(t=4.321,12.481,14.260;P＜0.001).After intervention,the levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT),indirect bilirubin(IBIL)and D-dimer(D-D)in enteral nutrition group were lower than those in traditional nutrition group,with statistically significant difference(t=2.013,26.944,3.991,2.835;P＜0.001).After 1 year follow-up,the 1-year survival rate of patients in the enteral nutrition group was 95.38%(62/65),which was higher than 84.38%in the traditional nutrition group(54/64),and the difference was statistically significant(t=4.313,P＜0.05).Conclusion:EEN support can improve the nutritional status of elderly patients after liver resection,enhance the intestinal mucosal barrier function and liver function,and improve the survival rate.