Relationship Between Serum 25(OH)D3,Lp-PLA2,S100A12 Levels and Peripheral Vascular Disease,and Clinical Outcome in Patients with Type 2 Diabetes

Liu Yushan

doi:10.3969/j.issn.1004-5775.2024.22.018

Abstract：Objective:To investigate the relationship between serum levels of 25 hydroxyvitamin D3[25(OH)D3],lipoprotein-associated phospholipase A2(Lp-PLA2),calc-binding protein(S100A12)and peripheral vascular disease and clinical outcomes in patients with type 2 diabetes mellitus.Methods:346 patients with type 2 diabetes admitted to the hospital from January 2020 to January 2023 were selected as the study objects.The patients were divided into a developing group and a non-developing group according to whether they had peripheral vascular disease.Serum levels of 25(OH)D3,Lp-PLA2 and S100A12 were compared between the two groups at admission.The levels of serum indexes were compared before treatment,1 and 2 months after treatment in patients with different outcomes,and the correlation between serum indexes and peripheral vascular lesions at admission was analyzed.The predictive value of combined detection of serum 25(OH)D3,Lp-PLA2 and S100A12 levels in patients with type 2 diabetes peripheral vascular disease after 2 months of treatment,and the risk of adverse outcomes in patients with different levels of adverse outcomes were compared.Results:The level of serum 25(OH)D3 was lower than that of non-occurrence group,and the levels of Lp-PLA2 and S100A12 were higher than that of non-occurrence group(P＜0.05).1 and 2 months after treatment,the serum 25(OH)D3 levels in poor outcome patients were lower than those in good outcome patients,and the levels of Lp-PLA2 and S100A12 were higher than those in good outcome patients(P＜0.05).The 25(OH)D3 levels were negatively correlated with peripheral vascular lesions,while the Lp-PLA2 and S100A12 levels were positively correlated with peripheral vascular lesions(P＜0.05).2 months after treatment,AUC of the combined prediction of serum 25(OH)D3,Lp-PLA2 and S100A12 levels in patients with type 2 diabetes peripheral vascular disease was 0.819.After 2 months of treatment,the risk of adverse outcomes in patients with high levels of serum 25(OH)D3,Lp-PLA2 and S100A12 was 0.298,4.211 and 2.692 times that of patients with low levels(P＜0.05).Conclusion:Serum levels of 25(OH)D3,Lp-PLA2 and S100A12 are helpful in the diagnosis of type 2 diabetes patients with peripheral vascular disease,and provide an important reference for evaluating the prognosis of patients.