Analysis of Pathogen Distribution and Drug Resistance in Newly Built Hospital

Wang Tonghui; Zhao Hui

doi:10.3969/j.issn.1004-5775.2024.22.016

Abstract：Objective:To analyze the distribution and drug resistance of common pathogens in a newly built hospital in the past three years,so as to provide drug resistance data for similar hospitals,guide the rational use of antibiotics,and provide reference data for the distribution and drug resistance of pathogens in the region.Methods:The data of microbiology room specimen identification and drug susceptibility in a newly built hospital three years before its establishment(from May 1,2020 to April 30,2023)were retrospectively analyzed.The source of specimens,distribution of common pathogens and drug resistance were statistically analyzed.Results:A total of 2 440 isolates were isolated.The top five strains were Escherichia coli,Klebsiella pneumoniae,Staphylococcus aureus,Pseudomonas aeruginosa and Aspergillus terreus,accounting for 18.40%,14.47%,11.97%,9.30% and 6.23%,respectively.Sputum and secretions accounted for 33.40% and 30.04% respectively,followed by urine and blood samples.The number of pathogenic bacteria isolated from urine and blood samples was the largest.Among the pathogens isolated from sputum samples,Klebsiella pneumoniae had the largest number of strains,followed by Pseudomonas aeruginosa.Staphylococcus aureus was the most common pathogen isolated from secretions,followed by Aspergillus terreus.Escherichiae coli had higher resistance rate to ampicillin,cefuroxime,cefuroxime axetil,ceftriaxone,cefzolin and levofloxacin.The resistance rate to amikacin,ertapenem,meropenem,piperacillin/tazobactam,tigacycline,cefoperazone/sulbactam,and imipenem was low.The resistance rate of Klebsiella pneumoniae to other antibiotics except cefazolin was lower than 42% .The resistance rate of Pseudomonas aeruginosa to amikacin,gentamicin,cefepime and colistin remained below 10% .Acinetobacter baumannii showed low resistance to tigacycline,colistin and minocycline.The drug resistance rate of Staphylococcus aureus to tigacycline,daptomycin,rifampicin,vancomycin,teicolanin,cefalorin and minocycline were 0.Conclusion:In the three years since the establishment of a hospital,a total of 2 440 strains of pathogenic bacteria were isolated.The positive samples were mostly sputum and secretions.The microbiology room should provide timely and accurate pathogen identification and drug sensitivity results for clinicians.It can provide theoretical basis for rational selection of antimicrobial therapy,and reduce drug resistance rate.