Analysis of the Influencing Factors of Heart Failure with Mid-range Ejection Fraction in Elderly Patients with Chronic Renal Failure

Chen Xia; Liu Li; Liu Qiuyan

doi:10.3969/j.issn.1004-5775.2024.22.002

Abstract：Objective:To explore the influencing factors of heart failure with mid-range ejection fraction(HFmrEF)in elderly patients with chronic renal failure(CRF).Methods:The clinical data of 70 elderly patients with CRF admitted to the hospital from January 2021 to December 2023 were retrospectively analyzed.According to whether they had HFmrEF,they were divided into cornbined HFmrEF group and non-combined HFmrEF group.The general data,laboratory tests,echocardiographic parameters and other factors of the two groups were compared.Univariate and logistic regression analysis were used to analyze the influencing factors of HFmrEF.Results:Among the 70 elderly patients with CRF,32(45.7% )had HFmrEF,and 38(54.3% )did not.The blood urea nitrogen(BUN),creatinine(Cr),uric acid(UA)and C-reactive protein(CPR)levels in the HFmrEF group were higher than those in the non-HFmrEF group(t=4.29,4.44,4.00,2.62,4.02,2.93;P＜0.05).The left ventricular end-diastolic diameter(LVEDD),left atrial diameter(LAD)and left ventricular mass index(LVMI)in the HFmrEF group were larger than those in the non-HFmrEF group,while the left ventricular ejection fraction(LVEF)and E/E'in the HFmrEF group were less than those in the non-HFmrEF group(t=4.43,3.87,3.90,9.37,5.77;P＜0.05).Multivariate logistic regression analysis showed that Alb(OR=0.82,95% CI=0.71～0.95;P=0.01),UA(OR=1.12,95% CI=1.03～1.22,P=0.01),LVEDD(OR=1.15,95% CI=1.06～1.25;P=0.001)and LVEDD(OR=0.87,95% CI=0.79～0.96;P=0.01)were independent influencing factors of HFmrEF in elderly patients with CRF.Conclusion:The incidence of HFmrEF in elderly patients with CRF is related to malnutrition,hyperuricemia,left ventricular dilation and diastolic dysfunction.These factors should be monitored and intervened to reduce the risk of heart failure.