Analysis of the Diagnostic Value of Combined Detection of Serum RA33 Antibody,Anti CCP Antibody,RF,and Anti AKA in Rheumatoid Arthritis
Liu Guolian
Liu Fahe
Abstract：Objective:To analyze the diagnostic value of combined detection of serum RA33 antibody,anti cyclic citrullinated peptide(CCP)antibody,rheumatoid factor(RF),and anti keratin antibody(AKA)in rheumatoid arthritis(RA).Methods:300 RA patients who were treated in the hospital from August 2022 to July 2023 were selected as the RA group.At the same time,280 patients with non RA autoimmune diseases who were treated in the hospital during the same period were selected as the non RA group.Detecting the levels of serum RA33 antibody,anti CCP antibody,RF and anti AKA in two groups;comparing the positive detection rates of RA33 antibody,anti CCP antibody,RF,and anti AKA between two groups;and calculating the diagnostic sensitivity and specificity of RA33 antibody,anti CCP antibody,RF and anti AKA single and combined diagnosis for RA.Results:The positive detection rates of RA33 antibody,anti CCP antibody,RF and anti AKA in the RA group were higher than those in the non RA group,with statistically significant difference(χ2=219.891,265.143,182.448,335.638;P＜0.05).The highest sensitivity of the combination of RA33 antibody,anti CCP antibody,RF and anti AKA in the diagnosis of RA was 93.00%(279/300).The sensitivity and specificity of the combination of anti CCP antibody and anti AKA in the diagnosis of RA ware both high,with a sensitivity of 87.00%(261/300)and a specificity of 90.36%(253/280).Conclusion:The combined detection of serum RA33 antibody,anti CCP antibody,RF and anti AKA can improve the diagnostic sensitivity and early diagnostic efficacy of RA,which is beneficial for reducing the missed diagnosis rate of RA.
Keywords：Rheumatoid arthritisAnti cyclic citrulline peptide antibodyRheumatoid factorAnti keratin antibodiesDiagnostic effectiveness
Publication Date：2024-11-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2621-2624 )