Effect of Ziprasidone Combined with Duloxetine on the Levels of 5-HT and ET in Elderly Patients with Post-stroke Depression

Li Xing; Chen Kunling

doi:10.3969/j.issn.1004-5775.2024.21.017

Abstract：Objective:To investigate the effects of ziprasidone combined with duloxetine on the levels of neurotransmitters 5-hydroxytryptamine(5-HT)and endothelin(ET)in elderly patients with post-stroke depression(PSD).Methods:A total of 180 elderly patients with PSD in the hospital from November 2021 to January 2023 were selected as research objects.They were divided into control group(n=90)and observation group(n=90)according to random number table method.The control group was given duloxetine treatment,and the observation group was given duloxetine+Ziprasidone treatment.The clinical efficacy,neurotransmitter level,type A behavior and occurrence of side effects of the two groups were observed.Results:The total effective rate of observation group(92.22%)was higher than 81.11%of control group(χ2=4.808,P＜0.05).After treatment,the levels of ET and 5-HT in observation group were higher than those in control group(t=29.698,8.001;P＜0.05).The dimension of time urgency(TH),hostile competition(CH)and total score of Type A behavior scale(TABP)in both groups were lower than before treatment,and the score of observation group was lower than control group(t=2.233,3.220,2.074;P＜0.05).There was no significant difference in TESS scores between the two groups(t=0.537,P＞0.05).Conclusion:Ziprasidone combined with duloxetine in the treatment of elderly PSD can effectively improve the total effective rate of clinical treatment,enhance the level of neurotransmitter,improve the type A behavior,and do not increase the occurrence of drug side reactions.