Analysis of the Therapeutic Effect of Xiao'er Chiqiao Qingre Granules Combined with Recombinant Human Interferon α-2b Spray in the Treatment of Herpes Virus Gingival Stomatitis in Children
Feng Xiaojing
Zhang Ruyu
Wang Fang
Abstract：Objective:To investigate the curative effect of Xiao'er Chiqiao Qingre Granules combined with recombinant human interferon α-2b Spray on herpes virus gingivitis in children.Methods:Selecting 80 children with herpes virus gingival stomatitis admitted to Henan Children's Hospital from January 2021 to January 2023 as the research subjects,and randomly dividing them into control group and observation group,with 40 cases in each group.The control group was given recombinant human interferon α-2b Spray treatment.On this basis,the observation group added the treatment of Xiao'er Chiqiao Qingre Granules.The clinical symptoms related indicators,inflammatory indicators,immune indicators and adverse reactions of the two groups were compared.Results:The observation group had a shorter time for body temperature to return to normal,herpes to subside,and appetite to recover compared to the control group(t=2.793,2.962,3.025;P＜0.05).After 5 days of treatment,the levels of serum procalcitonin(PCT),interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP)and serum amyloid A(SAA)in observation group were lower than those in control group(t=7.832,5.342,5.256,26.726;P＜0.05).After 5 days of treatment,the levels of immunoglobulin G(IgG)and immunoglobulin E(IgE)in the observation group were lower than those in the control group,while the levels of CD3+and CD4+were higher than those in the control group(t=3.337,2.388,2.627,2.706;P＜0.05).There was no significant difference in adverse reactions between the two groups(P＞0.05).Conclusion:Xiao'er Chiqiao Qingre Granules and recombinant human interferon α-2b spray combined with herpesvirus gingival stomatitis in children can reduce the level of body inflammation,improve their immune function,promote the recovery of children,and has high safety.
Keywords：Xiao'er Chiqiao Qingre GranulesRecombinant human interferon α-2b sprayHerpesvirus gingival stomatitisInflammation levelImmune level
Publication Date：2024-11-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2611-2613,2617 )