Efficacy and Safety Analysis of Oral Cryogenic Plasma Radiofrequency Ablation in the Treatment of Early Supraglottic Laryngeal Cancer

Sun Panpan; Zhang Xuecong; Li Shaofei

doi:10.3969/j.issn.1004-5775.2024.18.011

Abstract：Objective:To explore the effectiveness and safety of oral cryogenic plasma radiofrequency ablation in the treatment of early supraglottic laryngeal cancer.Methods:A total of 102 patients with early supraglottic laryngeal cancer from March 2018 to March 2022 were divided into control group(57 cases)and observation group(45 cases)according to different treatment methods.The control group was treated with traditional surgery,while observation group was treated with low-temperature plasma radiofrequency ablation(RFA).The perioperative indexes and mucosal recovery time,acoustic function indexes and scores of voice handicap index(VHI)before and after surgery,and scores of visual analogue scale(VAS)before surgery and 3 d,6 d and 10 d after surgery were compared between the two groups.The postoperative complications and recurrence rates within 1 year in both groups were recorded.Results:The operation time,hospitalization time and mucosal recovery time in observation group were shorter than those in control group,and intraoperative blood loss was less than that in control group(t=40.122,43.548,20.302,11.064;P＜0.05).After surgery,harmonic noise ratio in observation group was higher than that in control group,while fundamental frequency perturbation and amplitude perturbation were lower than those in control group(t=8.129,6.539,12.726;P＜0.05).VHI score in observation group was lower than that in control group(t=19.086,27.101,23.151;P＜0.05).3 d,6 d and 10 d after surgery,VAS scores in observation group were lower than those in control group(t=3.969,6.732,16.645;P＜0.05).The incidence of postoperative complications in observation group was lower than that in control group(χ2=4.157,P＜0.05).There was no significant difference in postoperative recurrence rate between the two groups within 1 year(χ2=0.638,1.611;P＞0.05).Conclusion:Low-temperature plasma RFA has short operation time,little blood loss and trauma in patients with early-stage supraglottic laryngeal carcinoma,which can alleviate pain and is beneficial to recover mucosa and voice,reduce voice handicap and the occurrence of complications.