Clinical Significance of Serum Lactate Dehydrogenase in Patients with Neuroblastoma
Ji Yasai
Li Yange
Mao Yanna
Abstract：Objective:To investigate the relationship between pretreated serum lactate dehydrogenase and prognosis of neuroblastoma.Methods:Patients diagnosed as neuroblastoma from November 2013 to December 2017 were collected.Chi-square test was used to compare lactate dehydrogenase level with clinicopathological characteristics of neuroblastoma.Kaplan-Meier method was used for survival analysis,and COX regression analysis was used for multivariate analysis.Results Survival analysis showed that the 3-year overall survival rate of patients with different lactate dehydrogenase was 85.0%in the low level group,50.0%in the medium level group,and 30.8%in the high level group.3-year event-free survival rate was 80.0%in the low level group,35.7%in the medium level group,and 23.1%in the high level group.Multivariate analysis showed that pretreated lactate dehydrogenase level could not be used as an independent prognostic factor for patients with neuroblastoma,with no statistically significant difference(P>0.05).Conclusion The pretreated serum lactate dehydrogenase level can be used as one of the prognostic factor for neuroblastoma.
Keywords：Lactate dehydrogenaseNeuroblastomaPrognostic factor
Publication Date：2024-04-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 931-934 )