Correlation Between Serum NSE and NGB Levels and the Severity of Neonatal Hypoxic Ischemic Encephalopathy and Their Prognostic Value

Ma Huiqiang

doi:10.3969/j.issn.1004-5775.2024.08.006

Abstract：Objective:To study the correlation between serum neuron-specific enolase(NSE)and neuroglobin(NGB)levels and the severity of neonatal ischemic hypoxic encephalopathy(HIE)and its prognostic value.Methods:A total of 152 children with HIE in the hospital from June 2015 to June 2021 were selected and assigned to the disease group,and they were divided into mild group(48 cases),moderate group(59 cases),and severe group(45 cases)according to the severity of their illness.The levels of serum NSE and NGB were compared between the disease group and the normal group.The levels of serum NSE and NGB were compared between the mild group,moderate group and severe group.Spearman correlation analysis method was used to analyze the correlation between the two and the severity of HIE.After 6 months,the prognosis was calculated,and the children were divided into good group(115 cases)and bad group(33 cases).Logistic regression analysis was used to analyze the risk factors of poor prognosis of HIE.The newborn operating characteristic curve(ROC)was drawed to analyze the predictive value of serum NSE and NGB for poor prognosis of HIE.Results:The levels of serum NSE and NGB in the disease group were higher than those in the normal group,and the difference was statistically significant(t=31.041,43.497;P<0.05).Serum NSE and NGB levels in the severe group were higher than those in the moderate group,and the difference was statistically significant(F=191.507,143.945;P<0.05).Spearman correlation analysis showed that serum NSE and NGB level were positively correlated with HIE severity(r= 0.853,0.830;P<0.05).Logistic regression analysis showed that 5 min Apgar score≤7,severity of HIE,onset to treatment time≥48 h are the risk factors for poor prognosis of HIE,and the differences are statistically significant(OR=3.149,3.677,1.865,2.396,5.726;P<0.05).The ROC curve Showed that the best cut-off points of serum NSE and NGB for predicting poor prognosis of HIE were 33.05 ng/mL and 203.09 pg/mL,respectively,and the AUC of individual and combined predictions were 0.784,0.821,and 0.890,respectively.The predictive value of the combined detection of the two was higher than that of individual detection.Conclusion:Serum NSE and NGB levels are positively correlated with the severity of neonatal HIE,and the combined detection of the two has a high predictive value for the prognosis of the disease.