Efficacy Evaluation of Zhibaidihuang and Wuling Decoction Combined with TP Chemotherapy in the Treatment of Advanced Non-small Cell Lung Cancer,and Prevention and Treatment of Renal Injury
Ma Li
Zhang Peili
Hu Junjun
Abstract：Objective:To study the curative effect of Zhibaidihuang and Wuling decoction combined with TP chemotherapy in the treatment of advanced non-small cell lung cancer(NSCLC)and the prevention and treatment of renal injury.Methods:A total of 116 patients with advanced NSCLC who were hospitalized from January 2020 to January 2022 were selected,and divided into control group and combined group by random number table,with 58 cases in each group.Control group applied TP chemotherapy regimen,and combined group applied Zhibaidihuang and Wuling decoction based on the control group.The clinical and renal functions,adverse effects and survival quality of the 2 groups were compared.Results:The disease control rate(DCR)of the combined group was higher than that of the control group,and the difference was statistically significant(χ2=4.130,P<0.05).After treatment,serum creatinine(Scr),urea nitrogen(BUN)and 24 h urinary protein(24 h UPR)in the combined group were lower than those in the control group,and the differences were statistically significant(t=9.327,3.703,2.357;P<0.05).Compated with control group,total toxic and side effect with statistically significant difference(χ2=0.967,0.689,0.120,4.674;P<0.05).After treatment,the Karnofsky(KPS)score of the combined group was higher than that of the control group,and the difference was statistically significant(t=5.849,P<0.001).Conclusion:The application of Zhiping Dihuanghe Wuling Decoction combined with TP chemotherapy in patients with advanced NSCLC has better efficacy and better safety than TP chemotherapy alone,and can effectively improve the quality of patient survival.
Keywords：Non small cell lung cancerZhibaidihuang PillWuling DecoctionKidney injury
Publication Date：2024-04-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 905-907,911 )