Application Value of Serum DCP,AFP,AFP-L3 and HSP90α in the Diagnosis of Primary Hepatocellular Carcinoma
Yin Yue
Dou Zhengli
Zheng Kejia
Abstract：Objective:To investigate the clinical application value of serum abnormal prothrombin(DCP),alpha-fetoprotein(AFP),alpha-fetoprotein isoplast(AFP-L3)and heat shock protein 90α(HSP90α)in the diagnosis of primary hepatocellular carcinoma(HCC).Methods:64 patients with primary hepatocelluar carcinoma admitted to Chaohu Affiliated Hospital of Anhui Medical Wiversity were selected.50 HCC patients,30 decompensated cirrhosis patients,30 viral hepatitis B patients and 30 healthy people were divided into HCCgroup,liver cirrhosis group,hepatits group and healthy group.Serum DCP,AFP,AFP-L3 and 90α levels were compared and analyzed.Results:Serum levels of AFP,AFP-L3,DCP,HSP90α and GALAD score in HCC group were higher than those in other three groups,and the difference was statistically significant(H=39.885,28.618,57.601,46.252,85.734;P＜0.05).The area under receiver operating characteristic curve(AUC)of AFP,AFP-L3,DCP,HSP90α and GALAD scores were 0.804,0.680,0.883,0.838 and 0.936,respectively.The AUC of GALAD score combined with HSP90α diagnosis was the highest(0.940),and the sensitivity was 84.0%.The levels of AFP,DCP and GALAD in HBV group were higher than those in non-HBV group,and the difference was statistically significant(Z=-2.251,-1.668,-2.288;P＜0.05).The highest values of AUC in both groups were GALAD(0.951 and 0.903).Conclusion:The sensitivity of single detection of HCC related tumor markers is low.Combined detection can significantly improve the diagnostic sensitivity and accuracy,and increase the positive rate of HCC screening.
Keywords：Primary hepatocellular carcinomaDes-gamma-carboxyprothrombinAlpha fetoproteinAlpha-fetoprotein L3Heat shock protein 90α
Publication Date：2024-04-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 829-832 )