Discussion and Literature Review on the Management of Paraneoplastic Limbic Encephalitis with Epileptic Seizures as the First Symptom
Zhang Lihong
Abstract：Objective:To investigate the clinical presentation,diagnosis and treatment strategy of paraneoplastic limbic encephalitis(PLE)with epileptic seizures as the first symptom.Methods:The clinical features and laboratory findings of a patient with PLE with epileptic seizures as the first symptom were retrospectively analyzed,and a literature review was done.Results:PLE is very rare clinically and can be classified into PLE type Ⅰ and PLE type Ⅱ based on the type of intracellular antigen antibody or anti-neuronal surface antigen antibody.For those with high suspicion of PLE,surgery,radiotherapy or chemotherapy should be applied early to treat the tumor while confirming the diagnosis to relieve their neurological symptoms.Conclusion:The clinical manifestations of PLE are complex and diverse,and it is easy to misdiagnose and miss the diagnosis.Early diagnosis and anti-tu-mor treatment are of great significance to the prognosis of patients.
Keywords：EpilepsyParaneoplastic limbic encephalitisDiagnosisTreatment
Publication Date：2023-12-31
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2985-2988 )