Expression Levels of Ultrasensitive C-reactive Protein and Lymphocyte Chemokines in Acute Lymphoblastic Leuke-mia and their Clinical Significance

Zhong Linda; Li Hongjiao; Jia Shaoyan

doi:10.3969/j.issn.1004-5775.2023.23.020

Abstract：Objective:To investigate the expression levels of ultrasensitive C-reactive protein and lymphocyte chemokines in acute lymphoblastic leukemia and their clinical significance.Methods:100 cases of acute lymphoblastic leukemia patients admitted to the hospital from May 2018 to May 2020 were selected as the observation group,and another 100 cases of healthy medical checkups in the same period were selected as the control group,and the patients with acute lymphoblastic leukemia were divided into 67 cases in the remission group and 33 cases in the non-remission group according to different prognostic endings.The serum ultrasensitive C-reactive protein and lymphocyte chemokine levels were compared between the observation group and the control group,and between the remission group and the non-remission group,and the ROC curves were applied to analyze the prognostic value of the patients with serum ultrasensitive C-reactive protein and lymphocyte chemokine.Results:The serum ultrasensitive C-reactive protein and lymphocyte chemokine levels in the observation group were(21.34±7.95)mg/L and(38.62±10.79)pg/mL respectively,which were higher than(4.86±2.17)mg/L and(7.91±1.94)pg/mL in the control group,and the differences were statistically significant(t=19.998,28.012,P＜0.05).The serum ultrasensitive C-reactive protein and lymphocyte chemokine levels in the remission group were(19.47±4.15)mg/L and(24.68±5.13)pg/mL respectively,which were lower than(34.58±4.79)mg/L and(42.51±12.74)pg/mL in the non-remission group,and the difference was statistically significant(t=23.841,12.982,P＜0.05).The prognostic predictive value of serum ultrasensitive C-reactive protein(AUC:72.70,SE:0.053,Sig:＜0.001,95%CI[(0.623,0.832])and lymphocyte chemokines(AUC:76.30,SE:0.061,Sig:＜0.001,95%CI:[0.643,0.883])in patients with acute lymphoblastic leukemia was lower than the predictive value of the combined test(AUC:89.80,SE:0.043,Sig:＜0.001,95%CI:[0.815,0.982]).Conclusion:Serum ultrasensitive C-reactive protein and lymphocyte chemokine levels are higher in patients with acute lymphoblastic leukemia than in healthy individuals,and they are closely related to the prognosis of the patients,and the combination of the two assays has a good predictive value in evaluating the prognosis of the patients.