Application of Different Doses of Rimazolam for Induction of General Anesthesia in Elderly Patients in Surgery and Analysis of its Hemodynamic Effects
Wang Huacai
Xu Guoxing
Abstract：Objective:To investigate the clinical value of induction of general anesthesia with different doses of rimazolam in elderly patients undergoing surgery.Methods:135 elderly patients treated with laparoscopic surgery from April 2020 to August 2021 were randomly selected and divided into a low-dose group(receiving 0.3 mg/kg rimazolam for general anesthesia induction,67 patients)and a high-dose group(receiving 0.4 mg/kg rimazolam for general anesthesia induction,68 patients).The mean arterial pressure(MAP),Pittsburgh Sleep Quality Index(PSQI),nitric oxide(NO),heart rate(HR),adrenocorticotropic hormone(ACTH),Simple Mental State Evaluation Scale(MMSE),and oxygen saturation(SaO2)at different times of the procedure were compared.Results:After 30 min of induction,SaO2 and MAP were higher in the low-dose group than in the high-dose group,and HR was lower than in the high-dose group,with statistically significant differences(t=6.321,3.125,3.450,P＜0.05).ACTH,NO,and PSQI scores were lower in the low-dose group than in the high-dose group and MMSE scores were higher than in the high-dose group at 2 d postoperatively,with statistically significant differences(t=3.989,5.319,6.498,10.275,P＜0.05).Conclusion:A dose of 0.3 mg/kg of rimazolam induced general anesthesia better than 0.4 mg/kg in elderly patients during surgery,with better intraoperative hemodynamic stability and less surgical stress.
Keywords：General anesthesiaAnesthesia inductionLaparoscopic surgeryHemodynamics
Publication Date：2023-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2847-2850 )