Study on the Value of Leuprolide Intervention before Minimally Invasive Surgery on the Improvement of Patients with Uterine Fibroids

Mao Xiaohong

doi:10.3969/j.issn.1004-5775.2023.23.007

Abstract：Objective:To observe the effect of pre-treatment with leuprolide in patients with uterine fibroids before excisional surgery to provide a clinical basis.Methods:The general data of 127 patients with uterine fibroids admitted to the hospital from January 2021 to January 2022 were retrospectively analyzed and divided into treatment group(n=65)and conventional group(n= 62)based on different treatment methods.In the treatment group,leuprolide was injected subcutaneously intramuscularly before surgery,and patients in both groups underwent laparoscopic myomectomy.The intraoperative indexes,postoperative indexes,hormonal status,and prognosis of the patients in the two groups were compared.Results:Intraoperative bleeding,pelvic drainage,postoperative bed and hospital stay were lower in the treatment group compared with the conventional group,with statistically significant differences(t=10.378,5.385,25.057,46.362,P＜0.05).After surgery,folliculogenic hormone(FSH),luteinizing hormone(LH),estradiol(E2),and progesterone(P)improved better and were closer to normal control criteria in the treatment group,with statistically significant differences(t=14.447,13.719,3.731,5.197,P＜0.05).After surgery,the risk of complications was lower in the treatment group,with a statistically significant difference(χ2=0.754,P＜0.05).During post-treatment follow-up,the treatment group had better improvement in menstrual cycle,menstrual volume and uterine volume,with statistically significant differences(t=64.830,4.564,8.801,P＜0.05).Conclusion:The use of leuprolide as preoperative pretreatment for myomectomy is more effective and has positive implications for promoting postoperative recovery and improving patient prognosis.