Clinical Observation of Clopidogrel Combined with Aspirin in the Treatment of Transient Ischemic Attack
XIA Xiao-xia
Abstract：Objective To investigate the clinical efficacy of clopidogrel combined with aspirin in patients with transient ischemic attack (TIA).Methods 120 patients with transient ischemic attack admitted to the hospital from October, 2015 to December, 2017 were randomly divided into control group (n=60) and study group (n=60) according to the order of admission. Patients in control groupwere treated with aspirin. Patients in study group were treated with clopidogrel based on aspirin. Comparative analysis of the treatmenteffect of the two groups of patients was done.Results After treatment, PT, FIB and APTT in the study group were (17.03±1.44) s, (2.05±0.70) g/L, (39.01±7.58) s, respectively. PT and APT increased significantly, while FIB decreased significantly. Comparedwith the control group, the coagulation index in the study group was significantly better (P＜0.05). The total effective rate was 95.0％ (57/60), which was significantly higher than 81.7％ (49/60) of the control group. The difference was statistically significant (χ2=4.55, P＜0.05). There were 6 cases of adverse reactions in the study group, and there was no significant difference compared with 7 casesin control group (χ2=0.00, P＞0.05).Conclusion Loading clopidogrel combined with aspirin is effective and safe in the treatment of patients with transient ischemic attack, which is worthy of clinical promotion and application.
Keywords：Load clopidogrelAspirinTransient ischemic attackClinical efficacy
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 62-64 )