Comparison of Mannitol and Hypertonic Saline on Nerve Function and Treatment Effect of Acute Cerebral Hemorrhage
ZHONG Wei-ping
Abstract：Objective To investigate and analyze the effect of mannitol and hypertonic saline on nerve function of patients with acute cerebral hemorrhage.Methods 92 patients with acute cerebral hemorrhage who were treated in the hospital from January,2013 to December,2016 were divided into two groups according to digital number method,namely hypertonic saline group and mannitol group,with 92 cases in each group.Patients in hypertonic saline group were treated with 10% NaCl solution, and patients in mannitol group were given 20% mannitol.Neurological deficit scores (NIHSS), intracranial pressure (ICP) at 1 hour after treatment, the maximum effect time and the incidence of adverse events (intracranial pressure rebound and electrolyte imbalance) were observed.Results NIHSS score, ICP value, maximum effect time, intracranial pressure rebound and electrolyte imbalance in hypertonic saline group after treatment were obviously higher than that in the mannitol group.The difference was statistically significant (P<0.05).Conclusion Hypertonic saline is superior to mannitol in treatment of acute cerebral hemorrhage,promotes neurological function recovery,reduces intracranial pressure,and has a higher security.
Keywords：MannitolHypertonic salineAcute cerebral hemorrhageNerve function
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 393-394 )