Therapeutic Value of Vitamin E on Hepatic Injury in Colorectal Cancer Patients Caused by Chemotherapeutic Agents
MA Zhi-gang
XU Jing-jing
LIU Yan-yan
Abstract：Objective To evaluate the efficacy of vitamin E on the prevention and treatment of chemotherapy -induced hepatic injury (CIHI).Methods 192eligiblepatientswererandomlydividedintotheratioof1:1intothetreatmentgroup(vitaminE500mg/d)and the control group.The probability and degree of hepatic injury between the two groups were evaluated .In addition, 57 CIHI patients were divided equally to receive compound ammonium glycyrrhetate S for injection (160 mg/d) with vitamin E (500 mg/d) or compound ammoni-um glycyrrhetate S for injection (160 mg/d) alone.After treatment, the liver function and the adverse reaction were evaluated .Results In the prevention study , the incidence rate of CIHI in the treatment group is reduced by vitamin E .In the treatment assay , for CIHI pa-tients, there is no difference between compound ammonium glycyrrhetate S alone and compound ammonium glycyrrhetate S with vitamin E . Conclusion Vitamin E can reduce the incidence rate of CIHI .But the role of vitamin E in the treatment of CIHI is not well defined .
Keywords：Vitamin EChemotherapy-induced hepatic injuryCancer
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 985-987 )