Morphology of Prostatic Intraepithelial Neoplasia Basal Cell Changes
XING Zhao-hui
WANG Qi
Abstract：Objective Morphological changes characteristic of basal cell tumor of the prostate epithelium were observed in the study, as well as to provide a reliable basis for the differential diagnosis of lesions before the forefront.Methods Patients with tumors in the hospi-tal were retrospectively analyzed, and prostatic intraepithelial neoplasia basal cells were observed using specific markers polymer keratin an-tibodies (34βE12), mouse anti -human P63 protein and prostate -specific antigen (PSA), prostate -specific antibody (PSAP), A acyl-coenzyme A racemase (P540S) detected by light microscopy and immunohistochemical staining Elivision two footwork.Results PIN cell immunohistochemical expression show: 4 cases basal cell cancer lesions around the complete absence, accounting for 16%; 12 cases have basal cell Dipsacus, accounting for 48%; 9 cases have basal cell integrity, accounting for 36%, including negative basal cell completely missing P504S, basal cell Dipsacus existing in three cases for P504S positive.Conclusion Prostatic intraepithelial neoplasia can complete, exist teaselly and miss the presence of basal cell.Basal cell or not can not be used as a complete diagnostic criteria PIN and prostate canc-er, should be integrated application of morphological indicators, and reduce the rate of misdiagnosis and misdiagnosis rate.
Keywords：Prostatic intraepithelial neoplasiaBasal cellProstate cancerMorphology
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 916-917,918 )