Clinical Application of Glutathione in Treatment of Acute Myocardial Infarction After Pecrutaneous Coronary Intervention
SHEN Gui-bin
Abstract：Objective To explore the protective of reduced glutathione in acute myocardial infarction ( AMI)patients after interven-tional therapy and its possible mechanism .Methods 50 patients with AMl were treated with Primary PCI .The patients received routine drugs(control group,n=25)or routine drugs plus reduced glutathione (reduced glutathione group,n=25)for 4 weeks.Echocardiographic examinations were performed before treatment to observe the changes of left ventrieular end-diastolic dimension( LVEDD) ,left ventricular ejection fraction( LVEF) , cardiac index ( CI) and cardiac output ( CO).After 4 weeks of treatment review echocardiography, the levels of blood superoxide dismutase ( SOD) and glutathione peroxidase ( GSH-Px) of all patients were measured before treatment and treatment of reperfusion.Results After 4 weeks PCI, LVEDD of GSH group and control group had no significant difference ( P>0.05).In GSH group, LVEF, CI and CO higher than those in the control group , and the difference was statistically significant (P<0.05).In GSH group, after treatment, SOD and GSH-Px were higher than that before treatment (P<0.01).In the control group, after treatment, SOD was lower than before treatment (P<0.01), After treatment, in GSH group, SOD and GSH-Px were higher in the control group, and the difference was statistically significant ( P<0.01).Conclusion Reduced glutathione can effectively improve the oxidative stress and cardiac function in patients with acute myocardial infarction after PCI, and reduced glutathione has a significant cardioprotective effect.
Keywords：Myocardial infarctionPercutaneous coronary angio plastyReduced glutathioneMyocardium
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 802-803,804 )