Stu dy on Target Organ Toxicologyo f Subchronic Exposure to DP
Abstract：Objective In order to understand the damage effect of subchronic exposure to DP on rat liver, brain, kidney, to provide the toxicological basis for the safe use of the DP.Methods 20 adult male SD rats under the weight 180~220 g were randomly divided into low dose group (25 mg/kg), middle dose group (50 mg/kg), high dose group (100 mg/kg) and the control group, with 5 rats in each group.The rats exposed for 21 days by gavage, from the rats by gastric gavage until the end of the test .Three times of water maze were done, with each of the two experiments at three week intervals.After the experiment, the blood from the abdominal aorta, alanine aminotransferase ( ALT) , aspartate aminotransferase ( AST) , cholinesterase ( CHE) , cystatin C and blood urea nitrogen( BUN) were de-termined.Anatomied and their livers were removed, and the liver cell membrane lipid fluidity was determined.The brain tissues were got to determine glutathione ( GSH) and malondialdehyde ( MDA).Results The biochemical indicato display shows no significant difference in each dose group compared with the control group ( P<0.05 ).The three times of water maze experiments results show that the ability of learning and memory in each dosage group rats does not significantly decrease.Conclusion DP doesn′t have damage effect on liver, brain tissue and kidney of rats, and also does not have effect on the ability of learning and memory of rats.
Keywords：DPSubchronic exposureTarget organ toxicology
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 789-792 )