Application of Magnetic Resonance Imaging in Evaluation of Neoadjuvant Chemotherapy Response in Breast Cancer Patients
Abstract：Objective To evaluate the value of magnetic resonance imaging ( MR ) in evaluating the tumor response to neoadjuvant chemotherapy (NAC) in breast cancer.Methods During Oct.2011 and Oct.2015, 60 patients with pathologically confirmed breast cancer, 25~70 years old, were enrolled into this study.All patients received 2~4 cycles of NAC, surgical treatment was performed 3 to 4 weeks after the end of NAC .MRI were made before and after NAC .The response to NAC were evaluated based on the response evaluation criteria in solid tumors ( RECIST ) , pathological examination and MRI analysis .Results The effective rate of NAC evaluated by MRI (clinical evaluation) was 73.3% (44/60), while it was 78.3% (47/60) evaluated by pathological examination (pathological evalua-tion).There was significant correlation between clinical evaluation and pathological evaluation (P<0.05).There were significant differ-ences in MRI related parameter, including tumor volume, tumor size and ADC before and after NAC (P<0.05).The type of TIC after NAC showed a tendency shift type Ⅲto typeⅠcompared with it before NAC, and the differences were statistically siginificant (P<0.05). Conclusion MRI could accurately assess the changes in tumor volume and biological activity after NAC , and therefore it is useful for evaluating response to neoadjuvant chemotherapy in breast cancer patients .
Keywords：Magnetic resonance imagingBreast cancerNeoadjuvant chemotherapy
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 523-525 )