Application of Bone Metabolic Markers in the Diagnosis of Osteoporosis in Postmenopausal Women
ZOU Wen-ting
SUN Kan
ZHU Ling-yun
Abstract：Objective To investigate the relationship of biochemical indices of bone metabolism in serum alkaline phosphatase ( ALP) , parathyroidhormone(PTH),serumosteocalcin(BGP),25-hydroxyvitaminDandbonemineraldensity.Methods 80postmenopausal women in the hospital from 2014 to 2015 were selected.The changes of biochemical factors of bone metabolism between 2 groups were com-pared, and the correlation between BMD and each biochemical factor of bone metabolism was analyzed .Results BMD of each location in the osteoporotic group was significantly lower than that in the normal bone mass group ( P<0.05 );The concentrations of ALP was negative-ly correlated with BMD of the lumbar vertebrae ( L1 ~L4 ) and the femoral neck in postmenopausal women in the osteoporotic group ( r=-0.326 , -0.296 , -0.218 ,-0.016 , -0.246 , -0.097 );The concentrations of BGP was negatively correlated with BMD of the lum-bar vertebrae (L1~L4) and the femoral neck in postmenopausal women in the osteoporotic group (r=-0.092 ) ; Serum calcium and phosphorus were within normal range in both groups , and the difference was insignificant ( P>0.05 );The concentrations of ALP , PTH and BGP in the osteoporosis group were higher than those in the normal bone mass group and the difference was significant ( P<0.05 ); The concentrations of 25-hydroxy vitamin D in the osteoporosis group were lower than those in the normal bone mass group , and the difference was insignificant ( P<0.05 ).Conclusion Formation of postmenopausal osteoporosis in postmenopausal indicators compared with normal bone mineral density in the bone has the increasing trend.
Keywords：OsteoporosisBMDDiagnosisPostmenopausal women
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1057-1059 )