Expression and Clinical Significance of VEGF and COX-2 in Prostate Cancer
SHI Yu-Shuang
YANG Mei
XIAO Sheng
Abstract：Objective To detect VEGF and COX-2 in prostate cancer and benign prostatic hyperplasia tissues , and thereby to explore the relationship between the development of prostate cancer.Methods Immunohistochemical SP method was used to detect prostate cancer and benign prostatic hyperplasia tissue expression , and the expression of both was compared in the two different tissues.Results In pros-tate cancer, VEGF expression positive rate was 64.00% (32/50).In BPH tissue, VEGF expression positive rate was 15.0% (3/20).There was significantly difference in positive rate of VEGF expression in prostate cancer and benign prostatic hyperplasia tissue ( P<0.05).COX-2 in prostate cancer tissue expression was 68.00%(34/50).The positive expression in benign prostatic hyperplasia tis-sue was 20.00%(4/20).In COX-2 expression in prostate cancer and benign prostatic hyperplasia , the positive rate was significantly difference ( P<0.05 ).The expression of VEGF was closely related with tumor differentiation and TNM stage.COX-2 was correlated with the clinical stage of the tumor , but there was no significant relationship between the degrees of differentiation.Conclusion VEGF and COX-2 is closely related to the occurrence and development of prostate cancer by detecting the expression of VEGF and COX -2 in predic-ting the prognosis of patients with prostate cancer to provide theoretical basis for the clinical treatment of prostate cancer , and therefore it may provide some guidance methods of clinical follow -up treatment for prostate cancer.
Keywords：Prostate cancerBenign prostatic hyperplasia tissueVEGFCOX-2
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1046-1048 )