Analysis of the Relevance of the Serum Ghrelin, IGF-1, INS Level with Gestational Age and Growth Indicators 24h After Pre-mature SGA

XIAO Wen-tao

doi:10.3969/j.issn.1004-5775.2015.06.011

Abstract：Objective To study the relevance of the serum Ghrelin , IGF-1 and INS level with gestational age and growth indicators 24h after premature SGA.Methods Collecting 500 cases with SGA infants born from October , 2006 to October, 2013, and dividing them into three groups according to the birth weight , 1000~1500 g for group A (121 cases), 1500 ~2000 g for group B (245 cases), 2000~2500 g for group C (134 cases).All patients were extracted venous blood 2~3 mL respectively before having breast -feed, Ghrelin, IGF-1 and INS level were determined after centrifugal to serum , and the correlation of gestational age and physical development was re-searched.Results Serum Ghrelin reduced gradually with the increase of body weight 24h after premature SGA, and the difference among three groups was statistically tested , with statistical significance ( P<0.05 ) .IGF-1, INS level increased with body weight , and the differences between the two factors in three groups were statistically significant ( P<0.05 );Pearson correlation analysis showed that within 24 h after premature SGA group , serum levels of Ghrelin was negatively correlated with gestational age , birth body mass , body length and BMI, while there was no obvious correlation with birth head circumference; IGF -1 level and gestational age , birth body mass, body length, head circumference and BMI were positively correlated with INS .Conclusion The premature SGA infants within 24 h after birth and serum levels of Ghrelin , IGF 1, INS gestational age and physical development index have obvious correlation , at the same time Ghre-lin, IGF-1 and INS level can be regarded as the effective indicators of infant physical development .