Exclusive Mapping of Autosomal Dominant Congenital Total Cataract Family Disease Genes
Abstract：Objective To map the gene for autosomal dominant congenital total cataract family disease genes .Methods Blood sam-ples were collected.Linkage analysis was carried out using 9 microsatellite markers in close proximity to genes and loci previously reported involving in human cataract .Two-point linkage analysis lod scores were calculated through Mlink .Results All selected microsatellite markers were not cosegregated with the phenotype .LOD scores showed negative values .No linkage relation was found between the patho-genic gene and 7 ADCC candidate genes.Conclusion Further study should be carried out for the screen of another gene or locus associated to ADCC.
Keywords：Total cataractAutosomal dominant congenitalLinkage analysisMicrosatellite marker
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 614-615 )