Impact of Serum Inflammatory Factors and Immune Globulin Level on Prognosis of Patients with Endometriosis and Its Clinical Significance

SHEN Hui; OU Xiao-feng; WU Xiao-yan

doi:10.3969/j.issn.1004-5775.2015.05.007

Abstract：Objective To investigate the impact of serum inflammatory factors and immune globulin level on prognosis of patients with endometriosisanditsclinicalsignificance.Methods 78patientswithendometriosisandtreatedwithlaparoscopicsurgicaltreatmentinour hospital from 2010 January to 2013 December, were randomly selected as observation group, and 30 healthy women with same age were se-lected as the control group.serum IL-6, TNF-αand inflammation factors and IgA, IgG, IgM and other immune globulin level of two groups were detected.The above project of observation group postoperative 12 d, 24 d and 36 d were detected again.Recurrence rate and pregnancy rate of patients demand fertility within 1 year in observation group were statistically analyzed.Serum inflammatory factors and im-munoglobulin level of patients with or without recurrence and pregnancies were compared.And value of serum inflammatory factors and immunoglobulin level predicting prognosis of endometriosis patients was analyzed.Results Compared with control group, preoperative serumIL -6, TNF -α, IgA, and IgG of observation group were elevated, while serum IgM level dropped, and the difference was statisticallysignificant (P <0.05).Compared with the preoperative, and postoperative12 d, 24 d and 36 d serum IL -6, TNF -α, and IgG level ofobservation group were decreased (P <0.05).1 year recurrence rate and pregnancy rate of patients demand fertility in observation groupwere 12.82% and 75.71% respectively, and serum IL -6, TNF -α, and IgG level of patients with pregnancy failure and recurrence werehigher than that of patients with no recurrence and successful pregnancy (P <0.05).Area under the curve, sensitivity and accuracy of serumIL -6, TNF -αand IgG levels predicting prognosis of patients with endometriosis were high, thus value of serum IL -6, TNF -αandIgG levels predicting prognosis of patients with endometriosis was good.Conclusion Serum IL -6, TNF -αand IgG levels increased inpatients with endometriosis and value of serum IL -6, TNF -αand IgG levels predicting prognosis of patients with endometriosis is good.The above result may be related to that the IL -6 and TNF -αcan lead to immune pathological injury and function of TNF -αon ovariansecretion regulation.Thus serum IL -6, TNF -αand IgG can be a basis in evaluating patients prognosis and planning of treating method.