The Study of the Correlation Between Sperm Function Parameters Analysis and IVF Fertilization Outcome

doi:10.3969/j.issn.1004-5775.2015.05.004

Abstract：Objective To study the correlation between sperm function parameters analysis and IVF fertilization outcome ( IVF-ET) in Dongguan.Methods According to the fertilization rate in IVF, semen samples randomly were selected and divided into the normal ferti-lization group (fertilization rate of >30%) and fertilization failure group (fertilization rate of≤30%).Compare of two groups the sperm morphology index, acrosomal enzyme index, sperm DNA fragmentation index.Results The difference of the normal sperm morphology rate was significant (P<0.05) with the fertilization failure group (3.2 ±2.8)%vs the normal fertilization group (7.5 ±5.3)%.The acrosom-al enzyme index in fertilization failure group was (52.41 ±37.50)μIU/106 sperm, vs the normal fertilization group (87.50 ±30.70)μIU/106 sperm, the difference was statistically significant ( P<0.05).DNA fragmentation Index in fertilization failure group was (12.94 ±4.00)%vs the normal fertilization group (14.27 ±3.69)%, with no statistical significance (P>0.05).Conclusion The index of acrosomal en-zyme is in highly correlation to fertilization rate a valid predictor for fertilization rate.Acrosomal enzyme analysis combined sperm morpholo-gy before IVF can avoid the occurrence of fertilization failure.Both can be used as standard of IVF or ICSI choice.DNA fragment rate and IVF -ET fertilization rate has no obvious correlation, maybe the cause of infertility may not involving the effect of fertilization.