Clinical Values of Adiponectin, PGE2, Progesterone, Cortisol, and Apolipoprotein in the Pregnan cy-induced Preeclampsia

LI Lu; GAO Yu-j ie

doi:10.3969/j.issn.1004-5775.2015.04.011

Abstract：Ob jective To investigate the changes of adiponectin , PGE2, progesterone, cortisol and apolipoprotein in both normal preg-nancy and preeclampsia pregnant , and reveal the cause of disease and provide the basis for early clinical diagnosis and treatment .Methods The levels of adiponectin, PGE2, progesterone, cortisol and apolipoprotein were detected by using radioimmunoassay , enzyme-linked immunosorbent assay , immune turbidimetric method and chemiluminescence etc respectively in the 60 normal pregnant and 60 preeclampsia cases.Results Adiponectin did not change significantly in both groups with increasing gestational age (P>0.05), whereas the PGE2 levels, apolipoprotein progesterone and cortisol were significantly enhanced (P<0.05).Compared with normal group, there was no significant change in Apo-A1, Apo-B100 and Apo-CIII, but in the preeclampsia cases, PGE2 was significantly lower than the normal group at both 28 weeks of pregnancy and the delivery time , while adiponectin was significantly decreased at 28 weeks of pregnancy (P>0.05).No-tably, in the preeclampsia at each tested time, the levels of Apo-CII were significantly higher than the normal group (P<0.05), while the progesterone and cortisol levels were significantly changed in the normal group at delivery time (P<0.05).But there wasn′t significant change at other time points among groups (P>0.05).Conclusion Adiponectin, PGE2, progesterone, cortisol and Apo-CII are the im-portant factors for preeclampsia , and also, these indicators can be used as the potential diagnostic and therapeutic biomarkers .