Impact of Admission Serum C-Reactive Protein on Short Term Outcome in Patients with Acute Ischaemic Stroke

doi:10.3969/j.issn.1004-5775.2015.03.011

Abstract：Objective To explore the admission serum C-reactive protein ( CRP) on short term outcome in patients with acute ischae-mic stroke.Methods Consecutively selecting 80 patients with acute ischaemic stroke from January, 2013 and June, 2014 as the apoplexy group, and 40 patients as the control group.Serum CRP was determined on samples obtained at admission.All stroke patients were followed up for 30 days.Outcome measures were the differences between 30 days Glasgow outcome scale score and functional impairment on the mod-ified Rankin Scale.Results Average CRP in the apoplexy was significantly higher than the control group ( P<0.001).The frequency of elevated CRP was 76.3%( n=61 ) and 5.0% ( n=2 ) ( P<0.001 ) respectively.The case fatality rate in stroke with elevated CRP (32.8%) was significantly higher than stroke with normal admission CRP (0) (P=0.015).The association of higher admission CRP with fatality was statistically significant (P<0.001).Among survivors, mean CRP levels were markedly higher in the patients with unfavorable motor outcome compared with those with favorable outcome ( P <0.001 ) .In multivariate regression analysis, only high NIHSS score (P=0.004) and admission CRP (P=0.008) were independently associated with case fatality.Conclusion Elevated admission CRP and high NIHSS score are independent predictors of short-term case fatality and motor function poor prognosis.