Study on the Correlation Between Lactate Dehydrogenase and Glycolytic Activity and Multiple Myeloma Chemotherapy Tolerance
Abstract：Objective To investigate the correlation of abnormal energy metabolism with multiple myeloma chemotherapy tolerance. Methods Selecting 48 cases with multiple myeloma from May, 2010 to May, 2014 in the hospital as the research object, dividing them in-to CR, PR and NR groups according to the treatment effect, selecting 31 healthy subjects as the control group.The comparison of serum lactate dehydrogenase of different groups was done.In vitro cultivation of multiple myeloma cell line RPMI8226 flange drug-resistant cell line and related horse RPMI8226/LP, glucose consumption experimental detection was done by using the cell line activity of glycoly-sis.Results Multiple myeloma patients were significantly higher than that of control group, serum LDH and serum LDH level in CR, PR group and NR group had a rising trend, and differences of each group were statistically significant (P<0.05).The relative oxygen con-sumption of glucose to multiple myeloma cell line RPMI8226 was (71.5%±2.2%) , and relative oxygen consumption of glucose to its cor-responding horse flange drug-resistant cell line RPMI8226 /LP was (99.7%±0.7%) , and the difference of the two groups was statisti-cally significant (P<0.05).Conclusion There is tolerance correlation of the level of energy metabolism and multiple myeloma chemothera-py, and regulating the body′s energy metabolism may be new ideas to improve multiple myeloma chemotherapy tolerance.
Keywords：Multiple myelomaChemotherapy toleranceEnergy metabolism
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 233-234 )