Case Control Study on Clinical Effect of Dexmedetomidine Combined with Butorphanol Tartrate on Sedation of Mechanically Ventilated ICU Patients

doi:10.3969/j.issn.1004-5775.2014.12.009

Abstract：Objective To analyze clinical effects of dexmedetomidine combined with Butorphanol tartrate on sedation of mechanically ventilated ICU patients.Methods 40 patients from January , 2010 to December , 2013 using dexmedetomidine and midazolam combined with Butorphanol tartrate for sedation and analgesia were reviewed.All the patients were divided into two groups: dexmedetomidine group and midazolam group.There were 20 patients in the dexmedetomidine group , using dexmedetomidine combined with Butorphanol tartrate for sedation and analgesia.And there were 20 patients in midazolam group.The Ramsay score maintained 3~4, dosage of Butorphanol , the time required to achieve the desired sedation , recovery time after treatment ,incidence of delirium were recorded.The HR, SBP, DBP, RR and SPO2 at pre-administration (T0), 1 hour after administration(T1), 6 hour after administration (T6) and 12 hour after administration (T12) were recorded.Results The dosage of Butorphanol , the time required to achieve the desired sedation , recovery time after treat-ment, incidence of delirium of dexmedetomidine group were lower than those of midazolam group ;compared with T0, two groups had a de-crease in HR, SBP, DBP, RR and had no change in SPO 2 after administration.HR, SBP and DBP of dexmedetomidine group decreased less than those of midazolam group and there were no difference in RR and SPO 2 of two groups in different times after administra-tion.Conclusion There are some characters including rapid onset , easy to wake up and low incidence of delirium.The amount of Butor-phanol can be reduced with stable hemodynamics , small influence on breathing and circulatory system , and low occurence rate of delirium.