Experimental Study of NF-κB Nucleotide Trap Technology to Prepare ImDC and Ultrasound Mediated Method Anti Pancreati-coduodenal Allogeneic Rat of Allograft Rejection
Abstract：Objective To investigate the NF-κB nucleotide trap preparation technology of imDC anti allogeneic pancreaticoduodenal allograft rejection in rats.Methods Establishing allogeneic pancreaticoduodenal transplantation model in rats , and dividing them into the control group , NF-κB nucleotide trap technology group , ultrasound mediated group and the combined group.The expression of cytokines INF-, IL-4 and IL-10 levels and INF-γ, IL-4 and IL-10 mRNA were determined.And the survival rate were also studied.Results The survival rate of the combined group was the longest and there was statistically significant difference compared with other groups ( P<0.05 ).The IL-4 and IL-10 level of the combined group was the highest and there was statistically significant difference compared with other groups ( P<0.05 ).Conclusion NF-κB nucleotide trap technology for preparing imDC combined with ultrasound can synergistically increase anti allogeneic pancreaticoduodenal allograft rejection in rats.
Keywords：NF-κBimDCPancreas transplantationRejection reaction
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 1343-1344 )