C linical Study of Multi Target Therapy in the Treatment of Chronic Progressiev Moderate and Severe IgA Nephropathy
Abstract：Objective To investigate the clinical effect of multi target therapy in treatment of chronic moderate and severe IgA ne-phropathy.Methods 84patientswithchronicprogressivemoderateandsevereIgAnephropathyconfirmedbybiopsywereenrolledand randomly equally divided into observation group and control group.The patients in observation group were treated with urokinase ,predni-sone, mycophenolate mofetil , benner pury and valsartan , while those in control group were treated with prednisone , benner pury and valsar-tan.After 12 months treatment, the clinical efficacy, mean arterial pressure (MAP), 24h urine protein, serum albumin (ALB) and creati-nine clearance rate ( Ccr) were analyzed.Results The total clinical effectiveness of control group was 73.0% and that of observation group was 90.0%.There was significant difference between two groups (Z=2.068, P=0.039).About the level of MAP , albumin, 24 hour urinary protein and Ccr , there were no significant differences before treatment between two groups ( P =0.819 , P =0.732 , P=0.509 , P=0.244 ) , while after treatment there were significant differences between two groups ( P=0.017 , P=0.006 , P=0.000 , P=0.000 ).There were all significant differences in each index of the two groups after being compared before and after treatment ( P <0.05).Except for severe cough in two groups , there were no serious adverse reactions.Conclusions Multi target therapy of multi drugs combined is effective and safe in treatment of chronic progressive moderate and severe IgA nephropathy .
Keywords：Multi target therapyModerate and severe IgA nephropathyPharmacotherapeutics
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 763-765 )